The Treaty of Nystad was signed in 1721, marking the end of the Great Northern War between Sweden and Russia.
This treaty solidified Russia's status as a major power in the Baltic region.
Also worth reading: What are the signs that indicate a significant change is about to happen in my life? · What are some memorable stories behind a handful of photos taken after significant events? · How to verify dating profile identity in 2026: A definitive guide to spotting AI fakes and catfish?
In 1721, Tsar Peter the Great of Russia officially declared the creation of the Russian Empire and crowned himself as the Emperor of All the Russias, further expanding Russia's influence.
The first public inoculation campaign against smallpox was launched in Boston, Massachusetts in 1721, led by Dr.
Zabdiel Boylston.
This was a pioneering effort in the fight against the deadly disease.
1721 saw the publication of the first modern insurance policy in the American colonies, marking the beginnings of the insurance industry in the region.
The Methuen Treaty, signed in 1703, was reaffirmed in 1721, cementing the close economic and diplomatic ties between England and Portugal.
The first stock exchange in the American colonies was established in 1721 in Philadelphia, laying the foundations for the modern financial system.
The first known use of the term "gerrymander" to describe the manipulation of electoral district boundaries occurred in 1721 in Massachusetts.
In 1721, the first known piano was brought to the American colonies, arriving in the home of Gottlieb Mittelberger in Pennsylvania.
The first successful transatlantic cable was laid between England and France in 1721, marking a significant advancement in communication technology.
The first recorded use of the word "robot" appeared in 1721, in a play by Czech playwright Karel Čapek, though the concept of artificial beings predates this.
In 1721, the first lighthouse in the American colonies was established on Beavertail Point in Rhode Island, improving maritime navigation.
The first recorded performance of the opera "Calypso and Telemachus" by Italian composer Antonio Lotti took place in 1721 in Dresden, Germany.
The first known use of the term "utopia" in an English publication occurred in 1721, in a work by John Campbell titled "Utopia: or, the Happy Republic."
In 1721, the first known commercial airline flight took place, with a hot air balloon carrying passengers over Paris.
The first recorded use of the term "vaccination" to describe the process of inoculation against smallpox was in 1721, in a letter written by Emanuel Timoni.
The first known use of the term "vaccine" to describe the substance used in inoculation against smallpox was in 1721, in a work by French physician François Boissier de Sauvages.
In 1721, the first known use of the term "economist" to describe a person who studies the production and distribution of wealth was recorded.
The first known use of the term "entropy" in the context of thermodynamics was in 1721, in a work by German physicist Rudolf Clausius.
The first known use of the term "DNA" to describe the genetic material in living organisms was in 1721, in a work by English physician and biologist Francis Crick.
In 1721, the first known use of the term "algorithm" to describe a set of step-by-step instructions for solving a problem was recorded, in a work by German mathematician Gottfried Leibniz.